DIFFERENTIAL EXPRESSION OF SURFACE MARKERS CD45RB AND CD44 ON MURINE CD8+ CELLS
نویسندگان
چکیده مقاله:
Considering the emerging importance of phenotypic markers as indicators of cell function and differentiation, we studied patterns ofCD44 and CD45RB expression in CD8+ murine T cells with prior exposure to antigen or staphylococcal enterotoxin B ( SEB ). Following in vivo priming with two purified protein derivatives (one from a virulent WHO strain and the other from an avirulent strain), T cell enrichment was performed on murine spleen cells and followed by in vitro restimulation with SEB. Flow-cytometry studies were done to monitor the expression ofCD44 or CD45RB. Results indicate that primed or memory CD8+ cells do not display any significant change in the expression ofCD45RB. The expression ofCD44 exhibited significant variations among unprimed and primed mice and between different antigens. We were also able to see differential expression relevant to the virulence of the bacterial strain. This study suggests that by activation of those populations ofCD8+, CD44+ cells, resistance to virulent bacteria occurs.
منابع مشابه
differential expression of surface markers cd45rb and cd44 on murine cd8+ cells
considering the emerging importance of phenotypic markers as indicators of cell function and differentiation, we studied patterns ofcd44 and cd45rb expression in cd8+ murine t cells with prior exposure to antigen or staphylococcal enterotoxin b ( seb ). following in vivo priming with two purified protein derivatives (one from a virulent who strain and the other from an avirulent strain), t cell...
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عنوان ژورنال
دوره 14 شماره 4
صفحات 359- 362
تاریخ انتشار 2001-02
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